Accelerating CAR-T process development: The power of process insight

Thursday 29th July 2021

8:00 PDT; 11:00 EDT; 16:00 BST; 17:00 CEST

As gene-modified cell therapies advance to address new indications, the need for rapid development of robust manufacturing processes becomes increasingly important. Process optimization sets the stage for clinical and commercial manufacturing and plays a foundational role in decreasing time to market and lowering costs of goods (COGs).

This series of case studies presents Design of Experiments (DOE)-driven development of process knowledge and rapid optimization of T-cell expansion in a miniaturized, automated multi-parallel setup as well as the phenotypic analysis of CAR-T cells with donor clustering.

Attendees will learn:

  • Accelerating media screening and critical process parameters (CPP) identification and optimization
  • Profiling CAR-T cells and donor clustering
  • Decreasing development time and COGs
Julia Hupfeld, Ph.D.
Advanced Therapies Expert
View Biography
Charlotte Barker

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