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The growing push for 3D cell culture models is limited by technical challenges in handling, processing, and scalability to high-throughput applications. To meet these challenges, we use our platform, magnetic 3D bioprinting, in which cells are individually magnetized and assembled with magnetic forces. In magnetizing cells, not only do we make routine cell culture and experiments feasible and scalable, but we also gain fine spatial control in the formation of spheroids and more complex structures. This presentation will focus on recent developments using this platform, particularly in cancer biology and immunology. Specifically, we will present methods and results for generating organoids for high-throughput screening (384- and 1,536-well), for phenotypic profiling of cell types within spheroids using real-time imaging and showing striking similarities between in vivo tissue and bioprinted cells. Overall, we use magnetic 3D bioprinting to create functionally and structurally representative spheroids for high-throughput screening.