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Accelerating the Discovery of New Antimicrobial Compounds

Thursday, April 26, 2018

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The increasing occurrence of multidrug resistant (MDR) bacteria is driving an urgent demand for the discovery of new antibiotics. The incidence of MDR bacteria is becoming a serious problem, especially in the hospital setting. High-throughput screening methodologies are important to speed up the discovery of new antibiotics.  Automation and miniaturization are important components in this process, since they significantly decrease the amount of drugs and reagents needed. 

During this webcast we will present some of the main assays used in the early stages of the antimicrobial compound discovery:

  1. Minimal Inhibitory Concentration (MIC) assay,
  2. synergy assay among 2 or 3 antimicrobial compounds,
  3. determination of the concentration of bacteria in liquid cultures,
  4. cytotoxicity assay
  5. bacterial growth/killing curves.
During the webcast we will discuss why and how we developed, and optimized protocols for the miniaturization and automation of these assays using the Echo Liquid Handler. The protocols developed have increased our capacity for screening new antimicrobial compounds by 400%, decreased the time for the preparation of several assays from several hours to minutes and allowed to routinely run assays that were not possible with a large number of compounds due to time and labour constrains.

This webcast has been produced on behalf of the sponsor who retains sole responsibility for content. About this content.
Riccardo Russo
Senior Research Associate
Rutgers, The State University of New Jersey New Jersey Medical School, Center for Biodefense
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Iain Russell
Senior Product Manager
Labcyte, Inc.
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Dr. Jayshan Carpen
Nature Research
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