Measuring Tissue Perfusion and PO2 in Conscious Animals to Investigate Organ Failure
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Live Date: Wednesday, May 9, 2018
Duration: 1 hour
During this webinar, sponsored by Scintica Instrumentation, Professor Clive May and Dr. Yugeesh Lankadeva, from the Florey Institute of Neuroscience and Mental Health in Melbourne, discussed their research investigating the causes of acute renal failure in large animal models, the effects of resuscitation with volume or vasopressor drugs on renal perfusion and oxygenation in sepsis, and the measurement of bladder urinary pO2 as a real-time estimate of renal medullary ptiO2.
First, they presented the development and validation of methodology to measure renal cortical and medullary tissue perfusion and oxygenation long-term in conscious animals. Specifically, they reviewed selective changes in renal cortical and medullary tissue perfusion and oxygenation in response to alterations in total organ blood flow and administration of drugs.
In addition, Professor May and Dr. Lankadeva shared data from their studies demonstrating changes in total renal blood flow, renal function and differential changes in renal cortical and medullary perfusion, and pO2 during resuscitation and in models of sepsis. They concluded the presentation with a focus on why the study of septic acute kidney injury is so important.
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