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In recent years, immunotherapy has become the most innovative and promising way to treat cancer by overcoming its hallmark of immune evasion. This approach targets modulation of the immune checkpoints that control antitumor T-cell responses by releasing the brakes on antitumor T cells. Current therapies focus on CTLA-4 and PD-1 surface receptors, with very promising results, but also with serious side effects. The limitations of these therapies and others tried so far (CAR T cells, dendritic cells, etc.) call for novel ways to improve their outcome. One approach is to induce the infiltration, activation, and expansion of CD8+ T cells in the tumor microenvironment (TME) by locally stimulating the innate immune response via secretion of IFNs and other cytokines.
This webinar will showcase efforts to find potential drug candidates that modulate the innate immune response utilizing fragment-based screening. The speakers will share results from screening campaigns using two biophysical methods for molecular interaction screening: MicroScale Thermophoresis (MST) and Temperature Related Intensity Change (TRIC), as well as a library of 2,600 fragments. They will also present preliminary results from ongoing crystallographic hit characterization and in silico hit optimization.
During this webcast you will learn about: