Sign Up:

(*) denotes required form field(s)

Our registration process uses cookies, by submitting this registration form you agree to our cookie policy.


Nanion Technologies - Webinar 

"Validation and optimization of automated patch clamp voltage-gated Ca2+ channel assays"

Date: 28. April 2020

Time: 4:00 PM CET / 10:00 AM EDT 

"Marc will outline the development, optimization and validation of a range of voltage-gated Ca2+ channel assays on the Patchliner automated patch clamp platform that were subsequently used in an 8 year drug discovery collaboration between Metrion Biosciences and a german pharma company. The project was successful in identifying several lead series of selective,state-dependent inhibitors of Cav2.2 N-type channels for use as novel, non-opioid analgesic. This required the creation of biophysical screening assays to identify the potency of small molecules against the resting and inactivated state of the human neuronal Ca2+ channels Cav2.1(P/Q type), Cav2.2 and Cav3.2 (T-type), some of which are notoriously difficult in terms of expression levels and current rundown.“


Marc Rogers
Chief Scientific Officer
Metrion Biosciences
View Biography
András Horváth
Application Scientist
Nanion Technologies
View Biography