Combining Telemetry and Ultrasound for Serial Investigation of Cardiovascular Function in Rats
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Live Date: Thursday, May 10, 2018
Duration: 1 hour
During this live webinar sponsored by Data Sciences International (DSI), Carlos Del Rio, PhD (Myokardia) presented a novel pre-clinical experimental design pairing DSI telemetry and high-resolution ultrasound to elucidate new insights of cardiac function in rats. There is significant power in the ability to serially record the same subject and track how disease progression affects cardiac function. Pairing these techniques allows conclusions to be made regarding load-independent cardiac function and mechano-energetic parameters of the heart.
In addition, Dr. Megan Fine, from DSI's Surgical Services team presented the advanced surgical model thats has been developed to allow left ventricular pressure collection in rats. Advice for techniques that can help improve the surgical success rates and telemetry signal quality was also provided, and examples of optimized data was shared. Finally, specific surgical and implant modifications that enabled concurrent collection of physiologic data from multiple telemetry implants in the same animal is explored.
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