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Deconstructing glioblastoma heterogeneity to develop new treatments

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Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is limited.

To overcome these limitations, McGill University neuroscience researchers performed single-cell RNA-sequencing (scRNA-seq) on 53,586 adult glioblastoma cells and 22,637 normal human fetal brain cells, and compared the lineage hierarchy of the developing human brain to the transcriptome of cancer cells.

Join Dr. Kevin Petrecca as he discusses this work and how understanding normal brain development reconciles glioblastoma development, suggests a possible origin for glioblastoma hierarchy, and helps to identify cancer stem cell-specific targets.

You will learn:

  • How to conduct lineage hierarchy analysis from single-cell RNA-sequencing data to identify progenitor populations underlying cancer initiation and progression
  • The cellular and molecular determinants of glioblastoma heterogeneity, originating in normal brain development
  • How to identify therapeutic targets specific to progenitor cancer stem cells
This webcast has been produced for 10x Genomics by Nature Research Custom Media. The sponsor retains sole responsibility for content. About this content.


Dr. Kevin Petrecca
Neurosurgeon, Associate Professor, William Feindel Chair in NeuroOncology Chief, Division of Neurosurgery Associate Chair
Department of Neurology & Neurosurgery at Montreal Neurological Institute-Hospital, McGill University
View Biography
Dr. Jayshan Carpen
Nature Research
View Biography