Revolutionary Approach to UV-Vis Measurements: SoloVPE® Slope Spectroscopy®

Previously Aired on January 19th, 2021

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Traditional UV/Vis spectroscopy uses fixed pathlengths to measure different analytes, such as nucleic acids, proteins, and cells from biological samples. These samples are often limited in volume or highly concentrated, which presents various challenges.

The SoloVPE® System uses a patented variable pathlength technology (VPT) to accurately measure the targeted concentration of various analytes. The system is able to measure concentrations without being dependent on sample volume or sample concentration, removing any dilution requirements.

In this webinar, we will review VPT and how it can be used in various applications from protein therapeutics to gene therapy. We will share real-world case studies demonstrating how leading biologic companies have integrated the SoloVPE System into their manufacturing workflow for release and in-process testing.

In this webinar, we will demonstrate:

  • The science of Slope Spectroscopy and why variable pathlength is better than fixed pathlength
  • Overview of the SoloVPE System and its benefits: 
    • No sample dilutions
    • Accelerated linear results
    • No baseline correction
    • Test low and very high concentration samples from 0.01 mg/mL up to 300mg/mL (MAbs)
    • Implement in the analytics/QC lab or in the production suite for at-line testing (IPT)
  • Review SoloVPE implementation in multiple applications: Quantitate proteins (A280, DNA/RNA, PS280, Gold Particle Testing, Plasmid purity)

Who should attend:

• Process Development Scientist

• Analytical Development Scientist

• Quality Control, Quality Assurance Scientist

• Manufacturing Science and Technology (MSAT) Scientist


Joe Ferraiolo
Associate Director Bioanalytics
C Technologies, Inc., a Repligen Company
View Biography
Mike Auerbach
American Pharmaceutical Review