TDM of Antibiotics Webinar
Available to View On Demand.
Antibiotic resistance is becoming an ever-growing threat to healthcare delivery. Both the antibiotic misuse and insufficient dosing are the main reasons for resistance emergence. Given the lack of novel antibiotics under development, optimized drug exposure is essential to suppress the spread of antibiotic resistance.
In the past therapeutic drug monitoring (TDM) has been employed only for antimicrobials with narrow therapeutic ranges, such as aminoglycosides. However, in recent years the knowledge about the altered pharmacokinetics in critically ill patients has led to a paradigm shift. Nowadays TDM of antibiotics is also advocated as a tool to guide dosage, ameliorating adequate drug exposure and therapeutic success in patients with severe infection, and at the same time minimizing the antimicrobial resistance. Accordingly, antibiotic TMD is becoming more widespread and increasingly recognized as a core element of hospital antibiotic stewardship programs.
This webinar reviews the basal requirements, indications and practical aspects for rational antibiotic TDM in the intensive-care setting, with a special focus on the beta-lactams that are the most widely used antibiotic class. Quantification techniques and respective bottlenecks for affordable de-centralized testing are also discussed.
- Antimicrobial resistance: a threat to global health
- Pharmacokinetic/Pharmacodynamic (PK/PD) target attainment
- The paradigm shift of antibiotic therapeutic drug monitoring (TDM)
- Antibiotic stewardship (ABS): Rational antibiotic TDM in severe illness
- Quantification techniques
- Limited services for antibiotic TDM: future challenges