Single-Cell Electrophysiology and 2-Photon Imaging in Awake Mice with 2D-Locomotion Tracking
ON-DEMAND // REGISTER TO VIEWLive Date: Thursday, April 4, 2019
Duration: 1 hour
In this webinar, experts present their research utilizing the Mobile HomeCage®, an experimental tool which ensures the stability required for high-precision neurophysiological techniques while allowing awake mice to navigate and explore their environment.
Case Study #1: Dr. Sarah Stuart and Dr. Jon Palacios-Filardo of the University of Bristol present their studies combining analysis of goal-directed behavior with whole-cell recordings from the hippocampus of awake mice. They also share tips for the surgery protocol and for adjusting the head fixation angle in order to facilitate exploratory behavior.
Case Study #2: Dr. Alexander Dityatev and Weilun Sun from the German Center for Neurodegenerative Diseases (DZNE) discuss 2-photon imaging of fluorescently labeled microglia in vivo in the context of neurodegenerative disease. They also present their recent data on the effects of different anesthetics on the microglial response to localized laser injury.
Case Study #3: Dr. Norbert Hájos from the Hungarian Academy of Sciences presents his lab’s research on the amygdala’s role in reward-driven behavior. He shares the challenges of making single-unit recordings with silicon probes during mouse locomotion and subsequent morphological identification of active neurons in the amygdala.
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