The spatial landscape of lung pathology during COVID-19 progression


Tuesday, July 13, 2021
8AM PDT | 11AM EDT | 4PM BST | 5PM CEST
 

Your details

Our registration process uses cookies, by submitting this registration form you agree to our cookie policy.

(*) denotes required form field(s)

  Register

The spatial landscape of lung pathology during COVID-19 progression


Tuesday, July 13, 2021
8AM PDT | 11AM EDT | 4PM BST | 5PM CEST
 

Overview

If you’ve already registered, please click here to log in to the webcast.

To date, interrogation of the interplay between infected cells and the immune system at sites of COVID-19 infection remains lacking. This webcast will describe use of high-parameter Imaging Mass Cytometry to target the expression of 36 proteins, to investigate the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2 at single cell resolution.

This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset revealed increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue.

A biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint was developed, enabling the pathophysiological characterization of the human lung from its macroscopic presentation to the single cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.

Learn about:

  • How COVID affects lung tissue composition and architecture, at single cell resolution, in the course of the disease
  • How the effect of COVID on the lung differs from other lung infections and respiratory diseases
  • Which cell types SARS-Cov2 targets in the lung and what pathways are triggered by infection in infected cells and neighboring cells
This webcast has been produced by Fluidigm, who retains sole responsibility for content. About this content.

Presenters

Presenter
Dr. Olivier Elemento
Professor and Director
Englander Institute for Precision Medicine
Weill Cornell Medicine
View Biography
Presenter
Dr. Jayshan Carpen
Moderator
Springer Nature
View Biography