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The Global Grants for Gut Health researchers will share some of their recent funded work.

Isabel Gordo explores how diversity emerges and can be maintained in the gut microbiome over the life of an individual host using a new in vivo long-term experimental evolution (ivLTEE) mouse system, where the evolution of a commensal lineage can be tracked in real time to provide novel insights into the missing process of intra-host evolution.

Niall Hyland discusses his work on the impact of the gut microbiome on drug metabolism, examining the expression of microbial drug-metabolizing enzymes and host drug-metabolizing genes. He will describe how manipulating the gut microbiome can influence host drug metabolism and the pharmacokinetic profile of psychotropic medications, and will discuss the possibility of developing a physiologically based pharmacokinetic (PBPK) model, incorporating a microbiome-mediated drug metabolism medications compartment, for predicting drug pharmacokinetics in patients.

Panel member Karen Scott will wrap up the webcast by announcing the scope of the next round of funding and sharing advice on how to get grant applications right.

The Global Grants for Gut Health is a competitive programme for investigator-initiated research into the human gut microbiota, supported by Yakult and Nature Research. This webcast is produced by Nature Research with support from Yakult. Nature Research retains sole responsibility for content. About this content.