Thursday 2nd July 2020, 8pm
The definition of metronomic chemotherapy varies, but generally it refers to repetitive, low doses of chemotherapy drugs designed to minimize toxicity and target the endothelium or tumour stroma as opposed to targeting the tumour. It is based on the chronic administration of chemotherapeutic agents at relatively low,minimally toxic doses, and with no prolonged drug-free breaks. It was originally developed to overcome drug resistance by shifting the therapeutic target from tumour cells to the tumour vasculature. Studies suggest that metronomic chemotherapy may be a multi-targeted cancer therapy, rather than a simple anti-angiogenic therapy. In addition to inhibiting tumour angiogenesis, metronomic chemotherapy might also restore the anticancer immune response and induce tumour dormancy.Metronomic chemotherapy combined with conventional chemotherapy, radiotherapy and/or targeted therapy is an emerging anti-cancer strategy.