Autophagy from Fundamental Mechanisms to Mechanical Stress in Physiology and Disease Originally Aired 28 February 2018,
Autophagy is known to be one of the major cell stress responses. Mechanical stress is important in the physiological functioning of many organs (e.g., stretching in muscles, compression in bones, shear stress in the circulatory system and in the kidneys). However, little information is available about the role of mechanical stress in regulating autophagy.
Recently we showed the role of autophagy in the integration of mechanical stress in the physiological adaptation of different organs (kidney, endothelium). In the kidney, autophagy is required to control epithelial cell size in response to the urinary flow in the proximal tubule. The fluid shear stress sensed by the primary cilium at the apical cell surface is responsible for the induction of autophagy. In the endothelium, the autophagic flux activation by the blood flow-induced shear stress is an atheroprotective mechanism.
Besides signaling in mechanical stress, our group has experience in the study of the basic molecular events regulating, autophagy in mammals. During this webinar, we will also discuss the molecular events that regulate the biogenesis of autophagosomes in mammals, notably during early steps of autophagy, such as emergence of omegasomes and phagophores.
- Understand the membrane dynamics of autophagasome biogenesis and its putative crosstalk with endoplasmic reticulum contact sites
- Understand the interplay between autophagy and the plasma membrane: role in mechanical stress integration